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Among the reported findings after 12 weeks: • BMI: 27.13 vs 28.49 • Waist circumference: 88.32 cm vs 92.21 cm • Fasting plasma glucose: 6.59 vs 7.68 mmol/L • 2-hour postprandial glucose: 8.24 vs 10.13 mmol/L • HbA1c: 6.69% vs 7.13% • HOMA-β: 50.03 vs 31.26 The paper also reported greater reductions in total cholesterol and triglycerides in the dorzagliatin combination arm, while adverse event rates were similar between the two groups

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Moreover, another study of DOX-induced nephrotoxicity in SD rats proved that L-theanine could protect the kidney by reducing the levels of oxidized glutathione (GSSG), gamma-glutamyltransferase 1 (GGT1), NF-κB p65, and the percentage of apoptosis indexes in the tissue and plasma, and increasing the levels of GSH and the activities of GPx, glutathione reductase (GR), and glutathione S-transferase (GST) (86)